Expression of EGFRvIII in Glioblastoma: Prognostic Significance Revisited
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چکیده
منابع مشابه
Expression and prognostic significance of CCL11/CCR3 in glioblastoma
Glioblastoma (GBM) is the most lethal primary nervous system cancer, but due to its rarity and complexity, its pathogenesis is poorly understood. To identify potential tumorigenic factors in GBM, we screened antibody-based cytokine arrays and found that CCL11 was upregulated. We then demonstrated in vitro that both CCL11 and its receptor, CCR3, were overexpressed and promoted the proliferation,...
متن کاملPrognostic effect of epidermal growth factor receptor and EGFRvIII in glioblastoma multiforme patients.
PURPOSE The epidermal growth factor receptor (EGFR) is overexpressed in approximately 50% to 60% of glioblastoma multiforme tumors, and the most common EGFR mutant, EGFRvIII, is expressed in 24% to 67% of cases. We sought to determine whether glioblastoma multiforme expression of either overexpressed wild-type EGFR or the mutant EGFRvIII is an independent predictor of overall patient survival. ...
متن کاملThe EGFRvIII variant in glioblastoma multiforme.
Glioblastoma multiforme (GBM) is the most common brain tumour and has the worst prognosis. Epidermal growth factor receptor (EGFR) gene amplification, mutation and re-arrangement (all of which enhance tumour growth, survival, progression and resistance to therapy) are frequently observed in primary GBM. The most common EGFR variant in GBM, the EGFRvIII, is characterised by a deletion of 267 ami...
متن کاملPrognostic significance of seizure in patients with glioblastoma multiforme.
BACKGROUND Several prognostic factors have been described but there are few studies evaluating the prognostic importance of seizure in patients with glioblastoma multiforme (GBM). AIMS To evaluate the prognostic importance of seizure at the time of the diagnosis of glioblastoma multiforme (GBM) and compare it with other known prognostic factors. SETTINGS AND DESIGN Between January 1994 and ...
متن کاملSurvival kinase genes present prognostic significance in glioblastoma
Cancer biomarkers with a strong predictive power for diagnosis/prognosis and a potential to be therapeutic targets have not yet been fully established. Here we employed a loss-of-function screen in glioblastoma (GBM), an infiltrative brain tumor with a dismal prognosis, and identified 20 survival kinase genes (SKGs). Survival analyses using The Cancer Genome Atlas (TCGA) datasets revealed that ...
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ژورنال
عنوان ژورنال: Neoplasia
سال: 2011
ISSN: 1476-5586
DOI: 10.1593/neo.111338